The artist has given the full amount of his £25k Mercury Prize cash to the trust for venues, which operates to preserve the United Kingdom's small concert spaces.
He was given the cheque on mid-October as his third album People Watching was declared the outstanding release of the previous year.
The musician has opted to donate the funds to the MVT, in acknowledgment of the essential function grassroots venues had in his early career.
"I wouldn't be doing what I am doing today if it weren't for all the shows I did around the region, and further afield, when I was just getting going," said the artist. "These spaces are iconic, but they are in difficulty."
From early 2023 onward, over 150 of these locations have ceased operations – roughly 16% of the entire UK sector.
In the last year, top acts including Pulp, Coldplay, Katy Perry and Ed Sheeran have all aided the trust in its attempts to support the industry, by adding a small levy to their ticket costs, which supports local stages.
Fender also joined in, generating over £100k on his live tour to support 38 local spots across Britain.
These funds assisted spaces that were facing potential shutdown due to challenges arising from water damage, blazes and bereavements, as well as regulatory hurdles, legal disputes and sound issues.
Some locations received monetary aid in upgrading amenities and gear that helped musicians and audiences.
"The idea that revenue from performances in large arenas helps the local stages, where it all starts for artists like me, is just sensible," Sam Fender has commented.
Fender is among several artists to give his award prize money to worthy causes.
In they won the award in the mid-90s for their record their work, lead singer Cocker declared that the group would give their cash to the non-profit the charity.
That year, musician Ms Dynamite divided her prize among multiple good causes, like the children's charity and a Sickle Cell organization.
"And I donated a £1,000 to my local community centre, to their gymnastics class, because I trained in gymnastics when I was a child and they lacked new equipment," the artist explained to a publication.
Two years ago, the band gave their funds to the local youth club that nurtured their act, alongside other independent music bodies.
And winners that year M People donated their award to a multiple sclerosis charity after a close contact was found to have the disease.
"Winning was sufficient," stated artist Small. "The cash was the extra but we didn't need the cherry, because we had the cake. So our success touched the lives of others."
Recently, the MVT revealed it had rescued a couple of grassroots venues in that region, by transferring them to local control.
The first in Southampton and The Croft in that location were bought under the community ownership scheme, which is funded by the arts council and supporters who purchase "stakes" in the properties.
