RAF Typhoon jets have conducted a mission with France's air force in a combined operation targeting an subterranean weapons facility in Syrian territory used by the IS group, per a report from the UK's MoD.
The location, identified by intelligence, was thought to be storing arms and explosives, the statement said, and was situated in hills just north of the ancient city of Palmyra in central Syria.
"Our fighter planes used laser-guided Paveway IV weapons to target a number of access tunnels leading to the site... early reports suggest the objective was successfully hit," officials stated.
There was no indication of any civilian casualties in the strike late on Saturday and all the aircraft returned safely, the defence officials confirmed.
The Typhoon FGR4s were supported by a Voyager tanker plane.
IS - also known as the so-called Islamic State - established extremist governance over parts of Syria and Iraq before its territorial defeat in 2019.
"This operation underscores British leadership, and commitment to stand shoulder to shoulder with our partners, to eradicate any revival of the terrorist group and their violent and radical beliefs in the region," the British Defence Secretary the minister said.
RAF aircraft have conducted overwatch operations over Syrian airspace to "forestall any efforts to regroup" of Islamic State following its routing at the climactic battle in Baghuz in 2019, the MoD reported.
"I want to thank the personnel of our armed forces who took part in this strike for their expertise and their valour," he commented. "They were part of thousands of British troops stationed over the festive period. This operation, to take out dangerous terrorists who endanger our way of life, highlights how UK forces are prepared to act, throughout the year, keeping Britain secure within its borders and strong abroad."
In December, the US military carried out what it termed a "massive strike" against Daesh sites in the country, following an attack claimed the lives of two American soldiers and a local interpreter in Palmyra.
The UN reports IS still maintains an estimated 5,000 to 7,000 militants in Iraq and Syria.